Work on the electronic nose (2008 - 2018) 


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The research study with the specially trained dogs had given promising results. The next step was to find a technical solution that could replace the dogs' sensitive and well-developed sense of smell in the future. At the beginning of the 2000s, the "electronic nose" was a topic in various research areas, but not in medical research. The idea of ​​the apparatus and instrument was born and the solution became just an electronic nose that could be used for diagnostics in medical contexts. We designed and authorized the building of a first simple prototype of the instrument. Thus, some laborious but very exciting work was begun to further develop the electric nose into a well-functioning instrument with high precision and speed, guaranteed valid ability, and an instrument that is reproducible and user-friendly.

Initially, gas chromatography and mass spectrometry were performed by ovarian cancer tumors. The study showed 11 specific VOCs that surround ovarian cancer and are characteristic of it. Based on this, specific sensors were selected for the new electronic nose that we began to build. In the next step, special air ducts were planned as well as a specially designed entry rod to use blood in the analysis. Newly designed scorecards were designed to make the instrument flexible for future use. The first test results showed 60% sensitivity, which was considered promising when the original electronic nose could not detect VOCs from cancer tumors. Then, the software began learning through several hundred series of tests. A total of 1,000 tests were carried out during the development phase. By 2015, when the algorithm for statistical processing of the signals was completed, a new study was launched. The study included 165 samples, 97 of which came from patients with ovarian cancer, while 68 samples were from healthy individuals. The results were striking and world-class with a sensitivity of 92% and a specificity of 93%.  The study was published in December 2018 in "Journal of Cancer Science & Therapy" entitled New construction of an electronic nose detects volatile organic compounds from blood, useful for the diagnosis and screening of ovarian carcinoma" i

A Swedish patent application was submitted following an international PCT (Patent Cooperation Treaty) application. Both were approved in 2017 and applications have now been submitted to US as well as to Europe.(Dec 2018)